Medora is a village in Macoupin County, Illinois, United States. The population was 419 at the 2010 census.
Medora is located at 39°10′34″N 90°8′30″W / 39.17611°N 90.14167°W / 39.17611; -90.14167 (39.176063, -90.141801).
According to the 2010 census, Medora has a total area of 0.38 square miles (0.98 km), all land.
As of the census of 2000, there were 501 people, 175 households, and 131 families residing in the village. The population density was 1,598.7 people per square mile (624.0/km²). There were 188 housing units at an average density of 599.9 per square mile (234.2/km²). The racial makeup of the village was 96.81% White, 0.20% Native American, 0.20% Asian, 1.20% from other races, and 1.60% from two or more races. Hispanic or Latino of any race were 1.60% of the population.
There were 175 households, of which 42.3% had children under the age of 18 living with them, 61.1% were married couples living together, 9.7% had a female householder with no husband present, and 25.1% were non-families. 23.4% of all households were made up of individuals and 14.9% had someone living alone who was 65 years of age or older. The average household size was 2.86 and the average family size was 3.39.
In the village, the population was spread out with 32.7% under the age of 18, 9.0% from 18 to 24, 26.7% from 25 to 44, 19.4% from 45 to 64, and 12.2% who were 65 years of age or older. The median age was 32 years. For every 100 females, there were 86.9 males. For every 100 females age 18 and over, there were 88.3 males.
The median income for a household in the village was $26,583, and the median income for a family was $28,750. Males had a median income of $35,000 versus $19,063 for females. The per capita income for the village was $11,052. About 10.0% of families and 12.4% of the population were below the poverty line, including 13.0% of those under age 18 and 28.6% of those age 65 or over.